Learn how Sulforaphane a ingredient in Rosadyn provides powerful benefits for rosacea treatment and for your health.

Broccoli sprouts, the youngest broccoli plants, first made the news in the late 1990s when researchers at the Johns Hopkins School of Medicine found that glucoraphanin, a potent anti-cancer compound, was highly concentrated in tiny young broccoli sprouts. The anti-cancer actions were due primarily to Sulforaphane’s ability to inhibit new blood vessel growth (angiogenesis) into tumors… causing them to shrink and die.  It’s germane to point out that the fully-grown broccoli stalks and florets we buy at the grocery store contain a biologically significant amount of glucoraphanin, but the tender, three-day old broccoli sprouts are naturally packed with as much as 100 times more glucoraphanin by weight.

Scientists have also found that topically applied sulforaphane has the ability to help protect the skin against the visible signs of sun damage, revitalize and repair skin, and reduce skin inflammation. Internally, sulforaphane has  anti-cancer, anti-inflammatory, anti-viral, detoxifying abilities and a host of other important health benefits.  It is also an excellent nutrition source as, it is high in vitamins A, B and C, calcium, magnesium, potassium, dietary fiber and folic acid, all of which are necessary for healthy skin, hair and anti-aging benefits.

How do broccoli sprouts convert to become Sulforaphane?

When broccoli sprout cells break open—which happens when the plant is damaged or eaten—glucoraphanin is released and mixes with a naturally occurring companion enzyme called myrosinase .(1) When these two compounds meet within the stomach, they form a new substance called sulforaphane.

Topical and oral Sulforaphane have the effect of activating cells’ production of what are known as “phase 2 enzymes.” One such enzyme, glutathione S-transferase activates Glutathione which is an essential antioxidant coenzyme that all cells make themselves from the three precursor amino acids – glycine, glutamic acid and cysteine. Glutathione continuously detoxifies our cells; neutralizing and eliminating free radicals and other toxic substances within the body.  It has also been shown to neutralize the DNA-damaging compounds the skin produces when struck by ultraviolet radiation or  ravaged by chronic inflammation or degenerative disorders.

What does this mean for Rosacea? Increased Glutathione production and angiogenesis blockade are two powerful weapons against rosacea symptoms and progression of rosacea.  This is because Glutathione reduces skin inflammation caused by rosacea-induced free radicals and dramatically slows new blood vessel growth, which is central to halting and even reversing rosacea.[J Dermatol Sci. 2010 Jun;58(3):171-6. Epub 2010 Apr 9]. [J Dermatol Sci. 2010 Mar;57(3):183-91. Epub 2010 Jan 8].

Normal Skin         Rosacea Angiogensis    Rosacea Skin + Sulforaphane


Broccoli Sprouts: Abundant Phytonutrients Benefit Your Skin

Sulforaphane has demonstrated a wide range of health benefits.

  • It supports your skin’s ability to detoxify, inhibits bacterial growth, has anticancer activity, and provides powerful protection against damage caused by UV radiation. It acts by stimulating production of enzymes (including glutathione S-transferase in the skin) that boost its ability to defend against sun damage and has been shown to neutralize the DNA-damaging compounds the skin produces when struck by ultraviolet radiation. It also appears to reduce inflammation, which can cause precancerous growths to transform into full-blown cancerous tumors.  A natural UV protection unlike topical “blockers,” sulforaphane  does not actually block sunlight from striking the skin.  Therefore, it does not take away the body’s ability to synthesize vitamin D, which is a critical nutrient for the body and mind.
  • Applied topically to the skin, concentrated broccoli sprout extract helps to minimize inflammatory processes, which can diminish redness, puffiness, and irritation, and improve the appearance, tone, and texture of your skin.1 In addition to protecting against—and even reversing—the appearance of sun-damaged skin, sulforapahane offers protection against the UV-induced oxidative damage that can lead to skin cancer. (2-3)
  • Broccoli sprouts also contain a variety of antioxidants, including beta-carotene, a naturally occurring form of vitamin A that can be enzymatically converted to retinol. Healthy human skin contains beta-carotene and the enzymes to convert it to other retinoid compounds(4)  In turn, naturally occurring beta-carotene can be converted to retinol in the body, yet it does not cause irritation, redness or other unpleasant side effects. In addition to antioxidant activity, beta-carotene stimulates collagen production, which helps to smooth wrinkles and maintain tighter and suppler skin. It also boosts the elasticity and resilience of the skin and calms ruddy complexions, evening the skin tone. (5)

The synergistic effect of these phytonutrients can help to support and protect the skin, enabling it to perform its most important function—serving as the first line of defense against environmental toxins, microbial pathogens and other harmful influences.

Phytonutrients Help Repair Sun-Damaged Skin

Today it is common knowledge that over exposure to the sun’s ultraviolet radiation can take a heavy toll not only on your skins appearance but its health, by serving as an agitator to other skin conditions as well.  Skin that has been damaged by the sun demonstrates obvious visible signs,  such as the appearance of fine lines and wrinkles. Over exposed skin is dry and rough, uneven, and loses  its firmness and elasticity.  Beyond general appearance, damaged skin can also form keratosis, various skin cancer and precancerous growths many years after a single sunburn response experienced in the teen years.  This damage can remain dormant just under the skin and crop up later in life… becoming a serious a medical issue.  While you can’t undo  periods of over-exposure to the sun’s harmful rays, you can strengthen and help repair your skin through sulforaphane and cruciferous phytonutrients ( green leafy vegetables and quality Nutraceutical supplements) .

So, what’s the best way to feed your body with these healthy “phytonutrients”?


Diet: Eating a diet rich with leafy green vegetables and cruciferous vegetables such as broccoli sprouts, cabbage, kale, and broccoli leafets, which provide many internal health benefits are a good souce of phytonutrients — as long as they are not overcooked — and preferably steamed.  What you may not know is that key phytonutrients in these vegetables can also visibly improve the health and appearance of your skin and help to repair and ward off progression of years of past sun damage.

Pharmaceutical-Grade Supplements: Lets face it, to achieve these beneficial effects one needs to take daily high doses.  These doses are impossible to achieve with natural ingestion of vegetables and thus supplementation must be added to achieve the critical active dose.  Only purchase pharmaceutical-grade, clinically-proven sulforaphane, like that found in Rosadyn™ or straight from a US manufacturer.

As with all nutrients, a balance must be achieved between natural intake and supplements, as the body absorbs the ingredients much more efficiently and the active ingredient is more bioavailable and bioactive within the cells of your body.  Bioactivity within cells is the only thing that matters for a supplement, because if you can’t absorb it through your intestines, it does not freely flow in the blood stream, and/or it’s not able to enter the cell and perform its function, then its effectively worthless.

Naturally Occurring Compounds Provide Powerful Health Benefits

Young broccoli from freshly sprouted seeds is particularly rich in a compound called glucoraphanin the prescursor of sulforaphane.  Glucoraphanin and other phytonutrients play a vital role in cancer prevention, immune system function,  heart health, detoxification of environmental toxins and the maintenance of healthy, youthful skin.

  • Heart & Cholesterol: The Japan Institute for the Control of Aging discovered that those who consumed 3½ ounces of broccoli sprouts daily for one week had lower blood cholesterol levels as well as an increase in HDL “good” cholesterol levels. Sulforaphane has also been shown to protect the vessels to the heart, the heart muscle and keep blood from clotting.
  • Cancer Protection:  A study in the “Lancet” Journal concluded that there is strong evidence for a protective effect of cruciferous vegetable consumption on many forms of cancer including lung, prostate and breast cancer. Much of the benefit is due to the fact that sulforaphane inhibits disease progression by blocking angiogensis to the tumors and  initiating the death of damaged cells. According to a study published in “Cancer Epidemiology,” the phytochemicals found in broccoli sprouts help to detoxify (or neutralize) carcinogenic substances from the body, reducing cancer risk.
  • Antibiotic Quality: Johns  Hopkins team discovered in 2002 that sulforaphane is a potent antibiotic against H. pylori when consumed regularly.  Recall that  H. pylori may play a role in rosacea. 

 

Why Sulforaphane is a key active ingredient in Rosadyn

Simply put, it helps to repair and protect your rosacea sensitive skin from the inside out like no other nutraceutical can

rosacea treatment rosadyn for flushing, triggers and facial rednessSulforaphane, the chemical extract abundant in the  Brassica family of vegetables, such as Broccoli Sprouts,  Broccoli, and cabbage, is one of the most intriguing Nutraceuticals of the decade.  This extract is one of the most potent anti-inflammatories yet discovered and perhaps the single best supplement for all rosacea symptoms and triggers.  While many nutraceuticals contain rosacea care ingredients, they may do so at a dose that has little beneficial impact.  In contrast, all Rosadyn ingredients, particularly sulforaphane, are at clinically effective doses.  Of equal importance, the ratio of each ingredient to the others was optimized to ensure maximum efficacy as a rosacea treatment.  This is important, as the interaction of ingredients can often render them ineffective in the body.

With respect to angiogenesis (growth of new blood vessels) blockade, Sulforaphane’s main initial use was in the prevention and treatment of cancerous tumors.  It completely blocked the formation of new blood vessels to the tumors, and in turn, the tumors shrank and died.  The fascinating clinical findings demonstrated that Sulforaphane had the unique ability to block all four stages of angiogenesis…. To date, no prescription medication can block all four stages of blood vessel growth.  In most cases they can block angiogenesis by 70% to 85%.  While there are many Universities and Pharmaceutical Companies trying to unravel the mysteries of Sulforaphane, the John’s Hopkins School of Medicine is the leader in this field of study.  Sulforaphane not only prevents angiogenesis in inflamed skin, but it binds onto old blood vessels, signals enzymes to cleave them into microparticles, and then delivers them to the lymphatic system, where unhealthy blood vessels are disposed of.  Uncontrolled blood vessel growth is central to the underlying pathophysiology of rosacea and flushing/blushing disorders and thus this ingredient is key to its treatment.

 Supplement Interactions: While sulforaphane is a great supplement for your health and rosacea, always discuss all supplements and medications with your physician to make sure there are no interactions.  If you have any further questions you can research this in the Herbal Physician Desk Reference (PDR).

Rosadyn’s Sulforaphane Extract is the Most Potent Non-Prescription Angiogenesis Inhibitor yet Discovered: It Blocks all Four Stages of Angiogenesis.

Learn about Rosadyn Ingredient blend and how they work together to help treat Rosacea.

 

References:

(1) Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19): 10367-72.
(2) Dinkova-Kostova AT, Jenkins SN, Fahey JW, et al. Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts. Cancer Lett. 2006 Aug 28;240(2):243-52.
(3)Talalay P, Fahey JW, Healy ZR, et al. Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17500-5.
(4) Ting W. Tretinoin for the treatment of photodamaged skin. Cutis. 2010 Jul;86(1):47-52.
(5) Cho S, Lee DH, Won CH, et al. Differential effects of low-dose and high-dose beta-carotene supplementation on the signs of photoaging and type I procollagen gene expression in human skin in vivo. Dermatology. 2010;221(2):160-71.
(6) “Biofactors;” Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts; M. Murashima, S. Watanabe, X.G. Zhuo, M. Uehara and A. Kurashige; 2004
(7)A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.Zhang Y, Talalay P, Cho CG, Posner GH. http://www.ncbi.nlm.nih.gov/pubmed/1549603?dopt=Abstract
Broccoli Sprouts Sloan Kettering http://www.mskcc.org/cancer-care/herb/broccoli-sprouts
Dr. A Weil MD http://www.drweil.com/drw/u/QAA401093/Better-Boost-From-Broccoli-Sprouts.html