The purpose of this rosacea article is to highlight the beneficial properties of Boswellia extract on rosacea symptoms and triggers. We will also discuss the most effective biological components in this extract and their optimal concentration for maximum efficacy.
New Research Indicates Inflammatory Enzyme may Play Key Role in Rosacea Development
New rosacea research and clinical case studies performed in 2012 and 2013 suggest that an inflammatory enzyme, 5-Lipoxygenase, may play an important role in rosacea-related skin inflammation, facial redness and facial flushing. This enzyme may also contribute to the overall progression of this inflammatory skin disorder.
5-Lipoxygenase is found in almost every cell throughout the body, especially facial skin cells. Once activated, this enzyme produces potent inflammatory substances called leukotrienes (luk-o-tri-enes) that diffuse to nearby cells and cause cellular damage and inflammation. This is especially true in rosacea-affected skin — these enzymes are hyperactive and produce abnormally high levels of leukotrienes to many innocuous stimuli.
Leukotrienes are also produced in high concentrations by certain foods and drinks — once released into the blood stream, these inflammatory leukotrienes travel to the facial skin and trigger flushing responses. Three areas of leukotriene research pertinent to rosacea include:
- Dermal Skin Inflammation
Leukotrienes cause significant dilation of blood vessels in facial skin and perpetuate the inflammatory skin cycle in rosacea skin. Additionally, leukotrienes stimulate the production of matrix metalloproteinases which are central to skin and blood vessel degradation. These substances destroy collagen, elastin and plasma membranes of nearby cells.
- Internal triggers that intensify facial flushing – diet
Leukotrienes are produced by foods that are high in fat content such as fast food, red meat and ‘TV’ dinners. This is a major reason why rosacea sufferers often flush after eating these types of meals. Alcohol (beer, wine and liquor) consumption also produces high concentrations of leukotrienes. While alcohol produces multiple dilator substances, leukotrienes are the most potent dilators synthesized after drinking alcohol. This is a major flushing trigger for most rosacea sufferers. ( also see articles on rosacea diet & nutrition)
- External triggers that stimulate facial flushing – weather and environment
Any skin irritant such as harsh skin care products, sun, heat, wind, cold, etc., will stimulate the release of leukotrienes from the epidermis. These inflammatory peptides then diffuse down to the dermis and cause blood vessel dilation, flushing and inflammation.
In Ayurvedic medicine Indian frankincense (Boswellia serrata) has been used in treating chronic inflammatory diseases like arthritis which paved the way to the use of Boswellia Extract for treating rosacea’s inflammatory process as well as other inflammatory medical conditions.
*learn more about Boswellia Extract
Natures Potent Inhibitor of 5-Lipoxygenase Enzyme
Boswellia extract is one of the most potent inhibitors of the 5-lipoxygenase enzyme — as strong as most oral prescriptions — and thus is an excellent nutraceutical for treating leukotriene formation.
At clinical concentrations boswellia extract can reduce the production of leukotrienes by up to 80%. This helps to reduce the inflammatory cycle of rosacea and quell rosacea flushing.
Rosadyn’s Pharmaceutical-Grade Boswellia Extract Sets New Treatment Standard
Rosadyn incorporated the most effective form of boswellia extract into its rosacea treatment nutraceutical.
It contains the key biological components, boswellic acids, at the highest possible concentration (55%). Most boswellia extracts on the market contain less than 10% to 12% boswellic acids and are not effective blockers of leukotrienes.
Rosadyn also contains the highest concentration of specific anti-inflammatory boswellic acid peptides that block leukotriene production and release, 3-acetyl-11-keto-beta-boswellic acid (AKBA 30%).
AKBA is key to blocking the enzyme that produces leukotrienes and eventually turns this enzyme off. Many boswellia extracts don’t selectively extract this important peptide or destroy it in the extraction process and thus are not biologically active.
Rosadyn’s Proprietary Absorption Enhancement Blend™ Key to Ensuring Maximum Bioavailability
Boswellia extract contains very large peptides that are hard to absorb in the intestine. This is a major problem for most extracts and simply overlooked. Extracts must be absorbed to have a biological effect in inflamed skin.
We added Digeseb® enzymes that cleave the peptides into small, active boswellic acid components, which allow this extract to reach maximum blood concentrations. We have also added Centrolex® phospholipids to help boswellia penetrate deep into rosacea-affected skin.
Without absorption enhancers most boswellia extracts never enter the blood stream and therefore cannot have a significant physiological effect.
Blocking 5-Lipoxygenase Enzyme Activity and Subsequent Formation of Inflammatory Leukotrienes is a Key Step Towards Healing Rosacea
Rosadyn’s unique pharmaceutical-grade boswellia extract is a key component in the treatment of rosacea symptoms and triggers. Boswellia’s AKBA peptides are central to this improvement because it not only blocks the enzyme that produces leukotrienes, but over time, it turns these enzymes off and normalizes their response to triggers.
Rosadyn’s inclusion of a proprietary absorption enhancement blend ensures that almost all of the extract reaches inflamed rosacea tissue.
While many physicians are now prescribing strong leukotriene inhibitors off-label for the treatment of rosacea, boswellia extract is as effective as most prescriptions, but without the side effects.
A natural solution to treating rosacea flushing, redness and triggers
Rosadyn nutraceutical can help you in your battle against rosacea because it targets one of the key underlying causes of rosacea and not just masks superficial symptoms like most other treatments.
Risk Free – Rosadyn is backed by a unconditional try it for 6 months to see a minimization of your facial reddness, decrease rosacea flair ups and flushing money back guarantee.