Study Overview

Rosacea treatment study - bioflavonoids show effectivness in treating rosaceaBelow we present a  rosacea treatment clinical study which demonstrates the superiority of natural Bioflavanoids compared to other popular rosacea prescription medications in the treatment of rosacea . In turn, these findings corroborate other clinical studies that validate  the effectiveness of natural treatment options for rosacea using peer-reviewed, human clinical studies.   This study also demonstrates the effectiveness of Rosadyn™  by extension, as each of Rosadyn’s ingredients were chosen on the basis of their performance in similar clinical evaluations as the one presented here.

This article is divided into two segments: a short summary of the study for those interested in just a high level overview and a more in-depth explanation for those desiring more granular detail.

Rosacea Study Basics & Quick Facts

Rosacea is a disorder of the facial blood vessels.  Rosacea blood vessels are genetically predisposed to structural damage, fragility, inflammation, leakiness and widespread overgrowth – the tell tail symptoms of rosacea, facial redness, broken blood vessels, swelling, burning and more.

Rosacea Treatment Comparison: The clinical study compares a bioflavanoid-based oral nutraceutical comprised of a proprietary blend of three bioflavanoid extracts with strong vascular-specific actions that work synergistically on reversing diseased blood vessels when used simultaneously in an oral delivery nutraceutical vs. traditional prescription based medications.

What is an Bioflavanoid? Bioflavanoids are extracts found in fruits, vegetables and various herbs that have strong anti-oxidant, anti-inflammatory, and, in some cases, potent vascular strengthening and blood vessel repair activity.

Rosacea Treatment Study Shows Bioflavanoids Out Perform Popular Medications In Reducing Rosacea Symptoms

In a recent three-month clinical study published in a peer-reviewed medical journal, titled, “Angioprotectors in the Treatment of Rosacea (March 2014)” Dr. Katsidadze and dermatology colleagues demonstrated that an all-natural, non-prescription, bioflavanoid-based oral nutraceutical could reverse most of the long-standing vascular pathophysiology and significantly reduce:

  • treatment-resistant rosacea redness (erythema)
  • broken blood vessels (telangiectasia)
  • vascular hyper-reactivity (flushing)

[message_box title=”Initial Study Results:” color=”red”]The study results showed that rosacea study patients treated with this bioflavanoid-nutraceutical outperformed the control group that was using topical anti-redness prescription treatments (metronidazole) and oral anti-redness prescription treatments (oral metronidazole, antihistamines and beta-blockers).  [/message_box]

Long Term Results Of Treating Rosacea With Bioflavanoid – Nutraceuticals

After the clinical study was completed the patients discontinued treatment for 12 months to see if the vascular symptoms and triggers would return.

The follow-up clinical examination of both treatment groups 12 months later demonstrated that:

  • the bioflavanoid-treated group’s facial erythema, telangiectasia and vascular hyper-responsiveness were still significantly better
  • the prescription-treated group of rosacea sufferers continued to worsen.

Verifying that these specific bioflavonoids had long-acting, positive effects on diseased blood vessels caused by rosacea.

[message_box title=”Clinical Study Demonstrates The Theory and Science Behind Rosadyn” color=”red”]Rosadyn™ is a non-prescription oral nutraceutical much like the bioflavanoid-based oral nutraceutical used in the clinical study – in fact, it contains the same three vascular-specific bioflavanoid extracts presented in the study at a clinically effective dose, but has incorporated them into a specialized oral nutraceutical containing proprietary enzymes and phospholipids for enhanced delivery deep into the wall of diseased rosacea blood vessels.  The dramatic effect of the three-bioflavanoid blend in the rosacea clinical study and their similar clinical-strength incorporation into Rosadyn™  validates Rosadyn’s effectiveness in reversing rosacea erythema, telangiectasia and flushing. Notably, Rosadyn™ goes beyond these three ingredients, incorporating 8 other pharmaceutical-grade ingredients shown effective in clinical studies.  Each Rosadyn™ ingredient has been combined into a proprietary blend of natural inspired ingredients which maximizes its positive impact in helping to treat rosacea skin.  As such, Rosadyn™ wad developed to treat the underlying vascular and cellular disorders through the use of strong clinical-grade bioflavonoids and anti-inflammatory medicinal extracts.  Rosadyn™  was researched and tested for three years by Vascular Health Specialists, a dermatology-based research firm, along with a Board-Certified Dermatologist and a bio-medical researcher with a Ph.D. in Micro-Vascular Physiology.  Rosadyn™ was released to the general public in 2009 and has been successfully used by hundreds of rosacea clients for over 5 1/2 years.  It is germane to emphasize that Rosadyn™ contains four additional vascular strengthening bioflavanoids in addition to the three used in the clinical study –  making Rosadyn™  an effective natural treatment for rosacea as it targets, treats and helps to reverse the core vascular disturbances instead of just masking rosacea symptoms and avoiding rosacea triggers. [/message_box]

To the best of our knowledge, there are no oral or topical prescription medications that fix or cure rosacea-induced physical and functional defects at this time – But, the good news is that rosacea sufferers can control, minimize and halt the progression of rosacea symptoms and disorder.

Study In Depth Review – Bioflavanoid Rosacea Treatment Case Study

Over the last three decades pharmaceutical companies have developed dozens of topical and oral prescription treatments for rosacea.  The main drawback to these treatments is that they only target superficial symptoms such as rosacea papules, pustules and inflamed facial skin.  They do not treat or reverse the underlying cause(s) of the disorder and rosacea sufferers still have to avoid all their rosacea triggers while undergoing treatment.

While there are numerous hypotheses to the cause(s) of rosacea, most dermatological experts agree that the primary instigating cause centers around blood vessel pathophysiology in the dermal skin and this is confirmed by histological and Doppler-flow studies [1-4].  Blood vessels and lymphatic vessels (vessels that carry inflammatory proteins, immune cells and excess skin fluid back to the lymph nodes via clear lymph fluid) are genetically prone to physical damage, vascular wall inflammation, abnormal hyper-reactivity, fragility and uncontrolled blood vessel overgrowth (angiogenesis) — ultimately lead to inflammatory papules, pustules, fibrosis, swelling, facial redness (erythema), broken blood vessels (telangiectasia), flushing, blushing, skin inflammation and rosacea triggers [5-8].

To date, no oral or topical pharmaceutical treatment has been developed to treat rosacea-induced vascular pathophysiology [2].  Treatments do not repair physical abnormalities, normalize vascular hyper-responsiveness, strengthen blood vessel walls or stop uncontrolled angiogenesis.  Recently, one topical lotion has been developed to constrict superficial blood vessels in an attempt to reduce erythema and telangiectasia, but this treatment only lasts 6 to 8 hours and multiple peer-reviewed dermatologic studies have already been published warning of the potential side effects of this new treatment which can include rebound dilation, spontaneous flushing, chronic erythema, and persistent burning and stinging sensations.

Oral Nutraceutical that Treats Rosacea Blood Vessels Shows Promise for Rosacea Sufferers

In 2014 a new non-prescription oral rosacea treatment was clinically tested and released to the public.  This new oral nutraceutical was developed with carefully selected bioflavonoids that have multiple actions on the core vascular disturbances in rosacea [9-12]:

  • Strengthen weak, fragile rosacea blood vessels by stimulating production of healthy new collagen and elastin throughout all layers of the vascular wall
  • Reduce “leaky” blood vessels by reducing pore size in the outer wall
  • Reduce inflammation in the inner wall of rosacea blood vessels by turning off inflammatory enzymes
  • Normalize hyper-reactivity by stimulating several “calming” protein kinases in the muscular section of the vascular wall
  • Fix mild-to-moderate telangiectasia by stimulating repair enzymes in the basement membrane of the vascular wall
  • Strengthen the dermal architecture surrounding the blood vessel by stimulating healthy new production of collagen and elastin throughout the facial skin and turning off enzymes that break down collagen and elastin (ie collagenase and elastase).  Healthy new skin is physically tethered to all blood vessels and helps make them stronger and more resilient to flushing reactions
  • Act as strong antioxidants that scavenge free radicals before they can damage or dilate blood vessels.  At high clinical doses excess antioxidants work throughout each layer of the dermal skin to reduce skin inflammation

This is the best approach to treat rosacea symptoms and triggers because not only does it address the primary genetic defects in rosacea blood vessels, but it creates healthy new dermal skin, prevents future free radical damage and treats every layer of facial skin because it is delivered orally — as it enters the skin through the vascular system it treats the lower dermis, mid-dermis, upper dermis and even the outer protective epidermal layer of skin.

Clinical Study Highlights: “Angioprotectors in the Treatment of Rosacea”

Rosacea Bioflavanoid Treatment for Rosacea – Clinical Study Setup

  • 30 rosacea patients with treatment-resistant facial erythema and telangiectasia were selected for this clinical study
  • All 30 patients were being treated with oral and topical prescription treatments before commencement of the study (eg. Oral Antibiotics, Oral Metronidazole, Antihistamines, Topical Metronidazole) and stayed on the same prescription treatment protocol throughout the duration of the three-month study to serve as an overall baseline
  • The patients were then divided into two groups: The 1st Group (15 patients) only took the prescription medications, while the 2nd Group (15 patients) took prescription medications and clinical doses of the bioflavanoid-nutraceutical twice a day
  • The study lasted three months and all 30 patients were analyzed by the clinicians for statistically significant changes in erythema and telangiectasia


  • The 15 patients on the bioflavanoid treatment all presented with significant reductions in erythema and telangiectasia at the three-month evaluation mark.  They then stopped treatment with the bioflavanoid-nutraceutical.
  • The 15 patients who did not take the bioflavanoid-nutraceutical (control group) presented with no significant changes even though they were still on oral and topical prescription medications
  • All 30 patients returned 12 months later for re-analysis of symptoms.  The 15 control patients who did not take bioflavanoid-nutraceutical presented with increased erythema and telangiectasia – their rosacea continued to worsen.  The 15 patients who took bioflavanoid presented with significant clearance of facial erythema and modest, but significant, reductions in telangiectasia comparable to the three-month mark clearance values.  This demonstrated that the non-prescription, bioflavanoid-nutraceutical reversed much of the vascular damage and dysfunction and the clearance continued for at least 12 months after stopping bioflavanoid treatment.


  • The study revealed that this unique bioflavanoid-nutraceutica is an effective means for the treatment and prevention of the torpid relapsing forms of rosacea on erythematous stage of dermatosis

Effect of Rosadyn™ Oral Nutraceutical on Rosacea Erythema, Telangiectasia and General Vascular Dysfunction

Rosadyn is a non-prescription oral nutraceutical that contains the same exact proprietary — three-bioflavanoid blend — used in the clinical study plus it also contains four additional potent bioflavanoids at clinical doses and has an excellent 5½ year track record in the rosacea community.

What are the Main Active Ingredients in Rosadyn™ and How Do They Function?

  1. Rutin – a natural bioflavanoid found in high concentrations in apples and various teas.  Rutoside is the main active ingredient in Rutin that is responsible for strengthening blood vessels and reducing vascular wall inflammation.
  2. Hesperidin – a natural bioflavanoid primarily found in orange peels.  This is one of the best bioflavonoids for overall vascular health and protection.
  3. Chelated Zinc – a form of highly bioavailable zinc that increases the effectiveness of all bioflavonoids once they enter the cell membrane
  4. Eastern White Pine Bark Extract (Standardized to 95% Proanthocyanidin content) – this form of specialized pine bark contains several of the strongest bioflavonoids studied to date including oligomeric proanthocyandins, catechins and phenolic fruit acids.
  5. Mediterranean Olive Fruit Extract (Standardized to 15% Oleuropein and 5% Verbascoside) – the oleuropein and verbascoside bioflavonoids are unique to this extract and have potent anti-inflammatory actions that help normalize diseased rosacea blood vessels and surrounding skin cells.  These bioflavonoids also have one of the strongest free radical scavenging actions which protect future rosacea-induced damage and are responsible for long-term, sustained symptom clearance. [10,11 ]
  6. Yellow Sweet Clover Extract – to the best of our knowledge Rosadyn is the only rosacea treatment that contains this powerful bioflavanoid that has unique actions – it selectively targets lymphatic vessels – and repairs these very important vessels responsible for clearing skin inflammation.  No other bioflavanoid repairs lymphatic vessels and if these are not repaired then the inflammation that builds up in blood vessels and skin cells cannot be removed from rosacea-affected skin cells.  At clinical strength, this bioflavanoid was one of the most important additions to Rosadyn and is completely unique to rosacea treatments. [9,10,12 ]
  7. Sulforaphane Glucosinolate Extract – this ingredient is extracted from broccoli sprouts and was incorporated into Rosadyn due to its potent actions on multiple phases of rosacea dysfunction: (1) Sulforaphane activates the three primary endogenous antioxidant systems in blood vessels and skin cells – Superoxide Dismutase, Glutathione and Catalase – which are superb free radical scavengers and counter the dysfunction present in rosacea that inactivates all three protective enzymes, allowing inflammation to go unchecked.  (2)  Sulforaphane strengthens all blood vessels throughout each layer (not just the inner wall like Rutin) and reorganizes the connective tissue to reduce vascular hyper-reactivity.  (3) Sulforaphane is the single best natural ingredient for stopping uncontrolled angiogenesis.  It actually inhibits all four stages of uncontrolled blood vessel regrowth.  (4)  Sulforaphane also attaches to muccopolysaccharide chains on old angiogenic vessels and triggers enzymes to cleave these unwanted blood vessels and remove them.  We know of no other ingredient or pharmaceutical that has these unique and important actions. [9-12]

Our Opinion: Rosadyn™ Treatment  Recommendations

Based on the number of active ingredients, their concentrations and unique actions, Rosadyn is a superior product to the bioflavanoid-nutraceutical studied in the clinical trial for rosacea treatment.

While the clinical study only treated rosacea sufferers for three months and this resulted in long-term clearance, one must remember that rosacea is a progressive disorder with no current cure.

Longer treatment could have resulted in better resolution of erythema and telangiectasia.  We also know that it takes at least three skin cycles (each cycle is approximately 30 days) to stop the rosacea-induced inflammation and several more cycles to fix the damage and clear the inflammation.  That is why Vascular Health Specialists recommends at least six months of treatment with Rosadyn and varying treatment doses depending on the stage of rosacea and the individual’s response to treatment during the first one-to-two months.  This treatment protocol has worked on hundreds of hard-to-treat rosacea clients over 5½ years.

No Risk Guarantee: We offer a full six-month money back guarantee to anyone not satisfied with their results – a six month guarantee is unheard of in the supplement/nutraceutical world, but we believe in our product and have seen its efficacy over the years.  After six months of treatment, most rosacea sufferers can slowly reduce their dose to a low maintenance dose to ensure that clearance is maintained.


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  2. Sobottka, A. Rosacea 2009: New Advances in Pathophysiology, Clinical Staging and Therapeutic Strategies.  Hautarzt: 60(12):999-1009, 2009.
  3. Yamaski, R. The molecular pathology of rosacea.  J. Dermatol. Sci: Aug;55(2):77-81. 2009.
  4. McAleer, MA, Powell, FC. The pathophysiology of rosacea.  Dermatol Venereol: 144(6):663-71. 2009.
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  6. Neumann, E. and A. Frithz. Capillaropathy and capillaroneogenesis in the pathogenesis of rosacea.  Int J Dermatol 37: 263-266, 1998.
  7. Nunzi, E., A. Rebora, F. Hamerlinck, and R.H. Cormane. Immunopathological studies on rosacea.  Br J Dermatol 103: 543-551, 1980.
  8. Wilkin, J.K. “The red face: Flushing disorders”.  Clin Dermatol 11: 211-223, 1993.
  9. Physician Desk Reference Staff. PDR for Nonprescription Drugs (Physicians’ Desk Reference for Nonprescripton Drugs, Dietary Supplements & Herbs, 34th Edition) [Hardcover], 2013
  10. Physician Desk Reference Staff and David Rorvik.  PDR for Nutritional Supplements [Hardcover] 2nd edition, 2008
  11. Physician Desk Reference Staff.  PDR for Herbal Medicines, 4th Edition, 2007
  12. Michael T. Murray ND and Joseph Pizzorno Jr. ND. The Clinician’s Handbook of Natural Medicine, 2nd Edition, 2007